A comparative evaluation of intraperitoneal instillation and periportal infiltration of 0.375% ropivacaine with dexmedetomidine and nalbuphine as adjuvants for post-operative analgesia in laparoscopic cholecystectomy

Background: Intraperitoneal instillation (IPI) of local anesthetic agents into peritoneal cavity has proved to be an effective method post-operative analgesia in laparoscopic cholecystectomy (LC). The addition adjuvants such as narcotics or α2-agonists been proposed prolong the duration analgesia. Aims and Objectives: This study aimed compare IPI periportal infiltration ropivacaine plus dexmedetomidine with nalbuphine patients undergoing LC. Materials Methods: was a comparative, prospective, randomized controlled double-blind conducted on total 100 (American Society Anesthesiologists class I II) planned for LC who were randomly divided two groups 50 patients: Group Ropivacaine+Dexmedetomidine (RD) received 150 mg (0.375%) (1 μg/kg) diluted normal saline 40 mL Ropivacaine+Nalbuphine (RN) 10 mL. Post-operative pain assessed by Visual Analogue Score, time first request analgesia, amount rescue analgesics given 24 h side effects noted. Data analyzed Student’s independent t-test Chi-square test using SPSS version 20.0. Results: Overall Analog Scale scores (1.38±0.78 vs. 2.59±1.15), (7.3±3.74 4.2±2.71), analgesic consumption (82.4±15.34 158.5±16.19) significantly lower RD group compared RN group. Among adverse events, incidence nausea vomiting higher Conclusion: appears superior terms prolonged lesser requirement less complications.